Post Time: 2025-02-18
Error: No content files found.The mechanisms are complicated, but the logic is simple. Here's how they intertwine. When it comes to glycogen breakdown (glycogenolysis), your liver and muscle have different priorities… * liver’s gotta glucose-deliver * glycogenolysis → glucose 6-phosphate → glucose → ship out * muscle says, glucose is “mine!” * glycogenolysis → glucose 6-phosphate → glycolysis → ATP YouTube: Blog: Metabolism spreadsheet: Insulin & glucagon are hormonal “opposites” that work to control blood sugar & read this article anabolism vs. catabolism Glucagon says “α-ll” the glucose is gone * secreted by pancreatic α cells in response to low blood sugar * stimulates catabolic processes * stimulates liver to full report make & ship out glucose * acts largely through PKA (aka cAMP-dependent protein kinase) signaling Insulin says β-etter let some glucose in! * secreted by pancreatic β cells in response to high blood sugar * stimulates anabolic processes * stimulates liver to take in & store glucose * acts largely through PKB (Akt) signaling more on the regulation: YouTube: Blog: more on all sorts of metabolic stuff: & 302 Sp24 please click the following page course videos: more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 or search blog: #scicomm #biochemistry #molecularbiology #biology #sciencelife #science #realtimechem Further reading: Chandel N. S. (2021). Carbohydrate Metabolism. Cold Spring Harbor perspectives in biology, 13(1), a040568. Meyer, C., Dostou, J. M., Welle, S., & Gerich, J. E. (2002). Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. American Journal of Physiology-Endocrinology and Metabolism, 282(2), E419-E427. Alsahli, M., Shrayyef, M., & Gerich, J. E. (2017). Normal glucose homeostasis. Principles of Diabetes Mellitus, 1-20. (2016). Principles of diabetes mellitus.. Woerle, H. J., Meyer, C., Dostou, J. M., Gosmanov, N. R., Islam, N., Popa, E., Wittlin, S. D., Welle, S. L., & Gerich, J. E. (2003). Pathways for glucose disposal after meal ingestion in humans. American journal of physiology. Endocrinology and metabolism, 284(4), E716–E725.